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HIV-1 Structural Proteins Serve as PAMPs for TLR2 Heterodimers Significantly Increasing Infection and Innate Immune Activation

Immune activation is critical to HIV infection and pathogenesis; however, our understanding of HIV innate immune activation remains incomplete. Recently we demonstrated that soluble TLR2 (sTLR2) physically inhibited HIV-induced NFκB activation and inflammation, as well as HIV-1 infection. In light o...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Henrick, Bethany M., Yao, Xiao-Dan, Rosenthal, Kenneth Lee
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541371/
https://ncbi.nlm.nih.gov/pubmed/26347747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00426
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