Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma

The bioactive lipid sphingosine-1-phosphate (S1P) and its receptors (S1P(1–5)) play critical roles in many pathologic processes, including cancer. The S1P axis has become a bona fide therapeutic target in cancer. JTE-013 [N-​(2,​6-​dichloro-​4-​pyridinyl)-​2-​[1,​3-​dimethyl-​4-​(1-​methylethyl)-​1H...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: Li, Mei-Hong, Swenson, Rolf, Harel, Miriam, Jana, Sampa, Stolarzewicz, Erik, Hla, Timothy, Shapiro, Linda H., Ferrer, Fernando
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2015
Pynciau:
Drug Discovery and Translational Medicine
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538871/
https://ncbi.nlm.nih.gov/pubmed/26105954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224519
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