Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.

Mannosamine (2-amino-2-deoxy D-mannose) is shown here to block the incorporation of glycosylphosphatidylinositol (GPI) into GPI-anchored proteins. The amino sugar drastically reduced the surface expression of a recombinant GPI-anchored protein in polarized MDCK cells, converted this apical membrane-...

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Bibliographic Details
Main Authors: Lisanti, M P, Field, M C, Caras, I W, Menon, A K, Rodriguez-Boulan, E
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC452876/
https://ncbi.nlm.nih.gov/pubmed/1829673
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