Suppression of PGC-1α is critical for reprogramming oxidative metabolism in renal cell carcinoma

Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC) frequent activation of HIF-signaling induces a metabolic switch that promotes tumorigenesis. Here we dem...

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Publicat a:Cell Rep
Autors principals: LaGory, Edward L., Wu, Colleen, Taniguchi, Cullen M., Ding, Chien-Kuang Cornelia, Chi, Jen-Tsan, von Eyben, Rie, Scott, David A., Richardson, Adam D., Giaccia, Amato J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518559/
https://ncbi.nlm.nih.gov/pubmed/26119730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.006
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