Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes

The CRISPR/Cas system efficiently introduces double strand breaks (DSBs) at a genomic locus specified by a single guide RNA (sgRNA). The DSBs are subsequently repaired through non-homologous end joining (NHEJ) or homologous recombination (HR). Here, we demonstrate that DSBs introduced into mouse zyg...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ono, Ryuichi, Ishii, Masayuki, Fujihara, Yoshitaka, Kitazawa, Moe, Usami, Takako, Kaneko-Ishino, Tomoko, Kanno, Jun, Ikawa, Masahito, Ishino, Fumitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516963/
https://ncbi.nlm.nih.gov/pubmed/26216318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12281
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