NOSCAPINE RECIRCULATES ENTEROHEPATICALLY AND INDUCES SELF-CLEARANCE

Noscapine (Nos), an antitussive benzylisoquinoline opium alkaloid, is a non-toxic tubulin-binding agent currently in Phase II clinical trials for cancer chemotherapy. While preclinical studies have established its tumor-inhibitory properties in various cancers, poor absorptivity and rapid first-pass...

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Bibliografiske detaljer
Udgivet i:Eur J Pharm Sci
Main Authors: Mukkavilli, Rao, Gundala, Sushma R., Yang, Chunhua, Jadhav, Gajanan R., Vangala, Subrahmanyam, Reid, Michelle D., Aneja, Ritu
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516653/
https://ncbi.nlm.nih.gov/pubmed/26026989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2015.05.026
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