Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice

Suppression of type 17 immunity by type I interferon (IFN) during influenza A infection has been shown to enhance susceptibility to secondary bacterial pneumonia. Although this mechanism has been described in coinfection with gram-positive bacteria, it is unclear whether similar mechanisms may impai...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Lee, Benjamin, Robinson, Keven M., McHugh, Kevin J., Scheller, Erich V., Mandalapu, Sivanarayana, Chen, Chen, Di, Y. Peter, Clay, Michelle E., Enelow, Richard I., Dubin, Patricia J., Alcorn, John F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504975/
https://ncbi.nlm.nih.gov/pubmed/26001778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00338.2014
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