Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis

BACKGROUND: The objective of this study was to evaluate the expression levels of glycolytic markers, especially hexokinase-2 (HK2), using a three-dimensional multicellular spheroid model of human ovarian adenocarcinoma (SKOV-3) cells and to develop an epidermal growth factor receptor-targeted liposo...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Gandham, Srujan Kumar, Talekar, Meghna, Singh, Amit, Amiji, Mansoor M
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501223/
https://ncbi.nlm.nih.gov/pubmed/26185443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S82818
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