Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

BACKGROUND: Amyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer’s disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest. γ-Secretase modulators (GSMs) are small molecules that selectively decrease Aβ42. We have previously repo...

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Dades bibliogràfiques
Publicat a:Mol Neurodegener
Autors principals: Jung, Joo In, Price, Ashleigh R., Ladd, Thomas B., Ran, Yong, Park, Hyo-Jin, Ceballos-Diaz, Carolina, Smithson, Lisa A., Hochhaus, Günther, Tang, Yufei, Akula, Rajender, Ba, Saritha, Koo, Edward H., Shapiro, Gideon, Felsenstein, Kevin M., Golde, Todd E.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501119/
https://ncbi.nlm.nih.gov/pubmed/26169917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0021-z
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