Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies

Aims: Ectopic activation of tissue-specific genes accompanies malignant transformation in many cancers. Prolactin (PRL) aberrant activation in lung cancer was investigated here to highlight its value as a biomarker. Results: PRL is ectopically activated in a subset of very aggressive lung tumors, as...

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Dettagli Bibliografici
Pubblicato in:Antioxid Redox Signal
Autori principali: Le Bescont, Aurore, Vitte, Anne-Laure, Debernardi, Alexandra, Curtet, Sandrine, Buchou, Thierry, Vayr, Jessica, de Reyniès, Aurélien, Ito, Akihiro, Guardiola, Philippe, Brambilla, Christian, Yoshida, Minoru, Brambilla, Elisabeth, Rousseaux, Sophie, Khochbin, Saadi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2015
Soggetti:
Forum Original Research CommunicationsHistone Deacetylases (S. Chiocca, Ed.)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492736/
https://ncbi.nlm.nih.gov/pubmed/24512221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5581
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