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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
Cholesterol plays an important role in living cells. However, a very high level of cholesterol may lead to atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human HMG-CoA r...
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| Udgivet i: | Drug Des Devel Ther |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Dove Medical Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492635/ https://ncbi.nlm.nih.gov/pubmed/26170618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S84641 |
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