The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist

Patients who respond poorly to therapies for hepatitis C virus (HCV) infection display a characteristic phenotype with high basal hepatic interferon-stimulated gene (ISG) expression, but limited induction following interferon (IFN) treatment. The molecular pathways that mediate this refractory state...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Interferon Cytokine Res
Auteurs principaux: Read, Scott A., Tay, Enoch S., Shahidi, Mahsa, McLauchlan, John, George, Jacob, Douglas, Mark W.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2015
Sujets:
Research Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490708/
https://ncbi.nlm.nih.gov/pubmed/25734487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2014.0209
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