Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain controver...

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Vydáno v:eLife
Hlavní autoři: Aznar, Nicolas, Midde, Krishna K, Dunkel, Ying, Lopez-Sanchez, Inmaculada, Pavlova, Yelena, Marivin, Arthur, Barbazán, Jorge, Murray, Fiona, Nitsche, Ulrich, Janssen, Klaus-Peter, Willert, Karl, Goel, Ajay, Abal, Miguel, Garcia-Marcos, Mikel, Ghosh, Pradipta
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484057/
https://ncbi.nlm.nih.gov/pubmed/26126266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07091
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