Anchor-based classification and type-C inhibitors for tyrosine kinases

Tyrosine kinases regulate various biological processes and are drug targets for cancers. At present, the design of selective and anti-resistant inhibitors of kinases is an emergent task. Here, we inferred specific site-moiety maps containing two specific anchors to uncover a new binding pocket in th...

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Udgivet i:Sci Rep
Main Authors: Hsu, Kai-Cheng, Sung, Tzu-Ying, Lin, Chih-Ta, Chiu, Yi-Yuan, Hsu, John T.-A., Hung, Hui-Chen, Sun, Chung-Ming, Barve, Indrajeet, Chen, Wen-Liang, Huang, Wen-Chien, Huang, Chin-Ting, Chen, Chun-Hwa, Yang, Jinn-Moon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468516/
https://ncbi.nlm.nih.gov/pubmed/26077136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10938
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