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IRF-5-Mediated Inflammation Limits CD8(+) T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection
Inflammation is known to be necessary for promoting, sustaining, and tuning CD8(+) T cell responses. Following experimental Leishmania donovani infection, the inflammatory response is mainly induced by the transcription factor IRF-5. IRF-5 is responsible for the activation of several genes encoding...
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| Publicado no: | PLoS Pathog |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457842/ https://ncbi.nlm.nih.gov/pubmed/26046638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004938 |
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