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Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate

The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through analysis of a unique mcm allele targeting a specific ATPase activ...

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Publicado en:Mol Cell Biol
Autores principales: Tsai, Feng-Ling, Vijayraghavan, Sriram, Prinz, Joseph, MacAlpine, Heather K., MacAlpine, David M., Schwacha, Anthony
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438241/
https://ncbi.nlm.nih.gov/pubmed/25870112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01357-14
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