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Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate

The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through analysis of a unique mcm allele targeting a specific ATPase activ...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Tsai, Feng-Ling, Vijayraghavan, Sriram, Prinz, Joseph, MacAlpine, Heather K., MacAlpine, David M., Schwacha, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438241/
https://ncbi.nlm.nih.gov/pubmed/25870112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01357-14
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