Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate

The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through analysis of a unique mcm allele targeting a specific ATPase activ...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Tsai, Feng-Ling, Vijayraghavan, Sriram, Prinz, Joseph, MacAlpine, Heather K., MacAlpine, David M., Schwacha, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438241/
https://ncbi.nlm.nih.gov/pubmed/25870112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01357-14
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