Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction

High levels of oxygen (hyperoxia) are often used to treat individuals with respiratory distress, yet prolonged hyperoxia causes mitochondrial dysfunction and excessive reactive oxygen species (ROS) that can damage molecules such as DNA. Ataxia telangiectasia mutated (ATM) kinase is activated by nucl...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Resseguie, Emily A., Staversky, Rhonda J., Brookes, Paul S., O’Reilly, Michael A.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430709/
https://ncbi.nlm.nih.gov/pubmed/25967673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.04.012
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