Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4(+) CD25(+) Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice

BACKGROUND: The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. We previously showed that Fibrinogen-like-protein 2 (FGL2), a novel CD4(+)CD...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Wang, Junhua, Vuitton, Dominique A., Müller, Norbert, Hemphill, Andrew, Spiliotis, Markus, Blagosklonov, Oleg, Grandgirard, Denis, Leib, Stephen L., Shalev, Itay, Levy, Gary, Lu, Xiaomei, Lin, Renyong, Wen, Hao, Gottstein, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425495/
https://ncbi.nlm.nih.gov/pubmed/25955764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003755
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