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Activin/Nodal Signaling Switches the Terminal Fate of Human Embryonic Stem Cell-derived Trophoblasts

Human embryonic stem cells (hESCs) have been routinely treated with bone morphogenetic protein and/or inhibitors of activin/nodal signaling to obtain cells that express trophoblast markers. Trophoblasts can terminally differentiate to either extravillous trophoblasts or syncytiotrophoblasts. The sig...

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Foilsithe in:J Biol Chem
Main Authors: Sarkar, Prasenjit, Randall, Shan M., Collier, Timothy S., Nero, Anthony, Russell, Teal A., Muddiman, David C., Rao, Balaji M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423675/
https://ncbi.nlm.nih.gov/pubmed/25670856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620641
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