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Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma

Therapeutics targeting the BRAF kinase in cutaneous melanoma have significantly improved patient survival. However, durable responses in the face of metastatic disease are rarely realized where the problem of brain metastases is generally growing in magnitude. Tumor and stromal cells dynamically rem...

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Bibliografski detalji
Izdano u:Biomaterials
Glavni autori: Blehm, Benjamin H., Jiang, Nancy, Kotobuki, Yorihisa, Tanner, Kandice
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417483/
https://ncbi.nlm.nih.gov/pubmed/25934286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.03.041
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