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Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma

Therapeutics targeting the BRAF kinase in cutaneous melanoma have significantly improved patient survival. However, durable responses in the face of metastatic disease are rarely realized where the problem of brain metastases is generally growing in magnitude. Tumor and stromal cells dynamically rem...

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Podrobná bibliografie
Vydáno v:Biomaterials
Hlavní autoři: Blehm, Benjamin H., Jiang, Nancy, Kotobuki, Yorihisa, Tanner, Kandice
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417483/
https://ncbi.nlm.nih.gov/pubmed/25934286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.03.041
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