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MPTP’s Pathway of Toxicity Indicates Central Role of Transcription Factor SP1

Deriving a Pathway of Toxicity from transcriptomic data remains a challenging task. We explore the use of weighted gene correlation network analysis (WGCNA) to extract an initial network from a small microarray study of MPTP toxicity in mice. Five modules were statistically significant; each module...

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Publicat a:Arch Toxicol
Autors principals: Maertens, Alexandra, Luechtefeld, Thomas, Kleensang, Andre, Hartung, Thomas
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415653/
https://ncbi.nlm.nih.gov/pubmed/25851821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1509-6
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