Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL(+) leukemia cells

Interactions between the dual BCR/ABL and Src inhibitor bosutinib and the Chk1 inhibitor PF-00477736 were examined in BCR/ABL(+) leukemia cells, particularly imatinib-resistant cells, including those with the T315I mutation. Bosutinib blocked PF-00477736-induced ERK1/2 activation and sharply increas...

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Veröffentlicht in:Leuk Res
Hauptverfasser: Nguyen, Tri, Hawkins, Elisa, Kolluri, Akhil, Kmieciak, Maciej, Park, Haeseong, Lin, Hui, Grant, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413916/
https://ncbi.nlm.nih.gov/pubmed/25465126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2014.10.009
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