Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules. We synthesized two directed libraries of monomers, each comprised of a ligand, a connector, and a bioorthogonal linker elemen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wanner, Jutta, Romashko, Darlene, Werner, Douglas S., May, Earl W., Peng, Yue, Schulz, Ryan, Foreman, Kenneth W., Russo, Suzanne, Arnold, Lee D., Pingle, Maneesh, Bergstrom, Donald E., Barany, Francis, Thomson, Stuart
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398458/
https://ncbi.nlm.nih.gov/pubmed/25875098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121793
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