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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment
Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394617/ https://ncbi.nlm.nih.gov/pubmed/26225237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.18 |
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