PNA-Based Multivalent Scaffolds Activate the Dopamine D(2) Receptor

[Image: see text] Peptide nucleic acid scaffolds represent a promising tool to interrogate the multivalent effects of ligand binding to a membrane receptor. Dopamine D(2) receptors (D(2)R) are a class of G-protein coupled receptors (GPCRs), and the formation of higher-ordered structures of these rec...

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Foilsithe in:ACS Med Chem Lett
Main Authors: Dix, Andrew V., Conroy, Jennie L., George Rosenker, Kara M., Sibley, David R., Appella, Daniel H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2015
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394337/
https://ncbi.nlm.nih.gov/pubmed/25893044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500478m
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