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Protein–RNA specificity by high-throughput principal component analysis of NMR spectra
Defining the RNA target selectivity of the proteins regulating mRNA metabolism is a key issue in RNA biology. Here we present a novel use of principal component analysis (PCA) to extract the RNA sequence preference of RNA binding proteins. We show that PCA can be used to compare the changes in the n...
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| 發表在: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381048/ https://ncbi.nlm.nih.gov/pubmed/25586222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1372 |
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