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Protein–RNA specificity by high-throughput principal component analysis of NMR spectra

Defining the RNA target selectivity of the proteins regulating mRNA metabolism is a key issue in RNA biology. Here we present a novel use of principal component analysis (PCA) to extract the RNA sequence preference of RNA binding proteins. We show that PCA can be used to compare the changes in the n...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Collins, Katherine M., Oregioni, Alain, Robertson, Laura E., Kelly, Geoff, Ramos, Andres
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381048/
https://ncbi.nlm.nih.gov/pubmed/25586222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1372
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