HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages

BACKGROUND: Non-mac-tropic HIV-1 R5 viruses are predominantly transmitted and persist in immune tissue even in AIDS patients who carry highly mac-tropic variants in the brain. Non-mac-tropic R5 envelopes (Envs) require high CD4 levels for infection contrasting with highly mac-tropic Envs, which inte...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Musich, Thomas, O’Connell, Olivia, Gonzalez-Perez, Maria Paz, Derdeyn, Cynthia A, Peters, Paul J, Clapham, Paul R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373511/
https://ncbi.nlm.nih.gov/pubmed/25809903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0141-0
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