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Quorum-sensing Salmonella selectively trigger protein expression within tumors

Salmonella that secrete anticancer proteins have the potential to eliminate tumors, but nonspecific expression causes damage to healthy tissue. We hypothesize that Salmonella, integrated with a density-dependent switch, would only express proteins in tightly packed colonies within tumors. To test th...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Swofford, Charles A., Van Dessel, Nele, Forbes, Neil S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371937/
https://ncbi.nlm.nih.gov/pubmed/25737556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414558112
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