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Quorum-sensing Salmonella selectively trigger protein expression within tumors

Salmonella that secrete anticancer proteins have the potential to eliminate tumors, but nonspecific expression causes damage to healthy tissue. We hypothesize that Salmonella, integrated with a density-dependent switch, would only express proteins in tightly packed colonies within tumors. To test th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Swofford, Charles A., Van Dessel, Nele, Forbes, Neil S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371937/
https://ncbi.nlm.nih.gov/pubmed/25737556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414558112
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