Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase

Crystal structural data for (4S)-limonene synthase [(4S)-LS] of spearmint (Mentha spicata L.) were used to infer which amino acid residues are in close proximity to the substrate and carbocation intermediates of the enzymatic reaction. Alanine-scanning mutagenesis of 48 amino acids combined with enz...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Srividya, Narayanan, Davis, Edward M., Croteau, Rodney B., Lange, B. Markus
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371936/
https://ncbi.nlm.nih.gov/pubmed/25733883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501203112
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