Deletion of STAT5a/b in Vascular Smooth Muscle Abrogates the Male Bias in Hypoxic Pulmonary Hypertension in Mice: Implications in the Human Disease

Chronic hypoxia typically elicits pulmonary hypertension (PH) in mice with a male-dominant phenotype. There is an opposite-sex bias in human PH, with a higher prevalence in women, but greater survival (the “estrogen paradox”). We investigated the involvement of the STAT5a/b species, previously estab...

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Bibliografiset tiedot
Julkaisussa:Mol Med
Päätekijät: Yang, Yang-Ming, Yuan, Huijuan, Edwards, John G, Skayian, Yester, Ochani, Kanta, Miller, Edmund J, Sehgal, Pravin B
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: ScholarOne 2015
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365065/
https://ncbi.nlm.nih.gov/pubmed/25470773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00180
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