Inhibition of NF-kappa B signaling restores responsiveness of castrate resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor variants expression

Androgen receptor splicing variants (ARVs) which lack the ligand-binding domain (LBD) are associated with the development of castration-resistant prostate cancer (CRPC), including resistance to the new generation of high affinity anti-androgens. However, the mechanism by which ARVs expression is reg...

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Veröffentlicht in:Oncogene
Hauptverfasser: Jin, Renjie, Yamashita, Hironobu, Yu, Xiuping, Wang, Jingbin, Franco, Omar E., Wang, Yufen, Hayward, Simon W., Matusik, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362792/
https://ncbi.nlm.nih.gov/pubmed/25220414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.302
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