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Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts
Plasminogen activator inhibitor-1 (PAI-1) promotes or abates fibrotic processes occurring in different organs. Binding of PAI-1 to vitronectin, an extracellular matrix component, may inhibit vitronectin–integrin complex-mediated cellular responses in pathophysiological conditions. To investigate the...
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| Publié dans: | Lab Invest |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4361016/ https://ncbi.nlm.nih.gov/pubmed/24687120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.51 |
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