Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts

Plasminogen activator inhibitor-1 (PAI-1) promotes or abates fibrotic processes occurring in different organs. Binding of PAI-1 to vitronectin, an extracellular matrix component, may inhibit vitronectin–integrin complex-mediated cellular responses in pathophysiological conditions. To investigate the...

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Vydáno v:Lab Invest
Hlavní autoři: Zhong, Jianyong, Yang, Hai-Chun, Kon, Valentina, Fogo, Agnes B, Lawrence, Daniel A, Ma, Ji
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361016/
https://ncbi.nlm.nih.gov/pubmed/24687120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.51
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