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Rational stabilization of complex proteins: a divide and combine approach

Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, lar...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Lamazares, Emilio, Clemente, Isabel, Bueno, Marta, Velázquez-Campoy, Adrián, Sancho, Javier
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360737/
https://ncbi.nlm.nih.gov/pubmed/25774740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09129
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