Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

Glutamatergic systems play a critical role in cognitive functions and are known to be defective in Alzheimer’s disease (AD) patients. Previous literature has indicated that glial glutamate transporter EAAT2 plays an essential role in cognitive functions and that loss of EAAT2 protein is a common phe...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Takahashi, Kou, Kong, Qiongman, Lin, Yuchen, Stouffer, Nathan, Schulte, Delanie A., Lai, Liching, Liu, Qibing, Chang, Ling-Chu, Dominguez, Sky, Xing, Xuechao, Cuny, Gregory D., Hodgetts, Kevin J., Glicksman, Marcie A., Lin, Chien-Liang Glenn
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354363/
https://ncbi.nlm.nih.gov/pubmed/25711212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140413
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