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Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins

Cysteine is susceptible to a variety of modifications by reactive oxygen and nitrogen oxide species, including glutathionylation; and when two cysteines are involved, disulfide formation. Glutathione-cysteine adducts may be removed from proteins by glutaredoxin, whereas disulfides may be reduced by...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Mohanasundaram, Kaavya A., Haworth, Naomi L., Grover, Mani P., Crowley, Tamsyn M., Goscinski, Andrzej, Wouters, Merridee A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354306/
https://ncbi.nlm.nih.gov/pubmed/25805991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00001
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