Synthetic Consensus HIV-1 DNA Induces Potent Cellular Immune Responses and Synthesis of Granzyme B, Perforin in HIV Infected Individuals

This study evaluated the safety and immunogenicity of PENNVAX-B in 12 HIV infected individuals. PENNVAX-B is a combination of three optimized synthetic plasmids encoding for multiclade HIV Gag and Pol and a consensus CladeB Env delivered by electroporation. HIV infected individuals whose virus was e...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Morrow, Matthew P, Tebas, Pablo, Yan, Jian, Ramirez, Lorenzo, Slager, Anna, Kraynyak, Kim, Diehl, Malissa, Shah, Divya, Khan, Amir, Lee, Jessica, Boyer, Jean, Kim, J Joseph, Sardesai, Niranjan Y, Weiner, David B, Bagarazzi, Mark L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351468/
https://ncbi.nlm.nih.gov/pubmed/25531694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.245
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