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Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

Cancer therapies that simultaneously target activated mammalian target of rapamycin (mTOR) and cell metabolism are urgently needed. The goal of our study was to identify therapies that effectively inhibited both mTOR activity and cancer cell metabolism in primary tumors in vivo. Using our mouse mode...

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Foilsithe in:Oncotarget
Main Authors: Andrade-Vieira, Rafaela, Goguen, Donna, Bentley, Heidi A., Bowen, Chris V., Marignani, Paola A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350354/
https://ncbi.nlm.nih.gov/pubmed/25436981
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