Pharmacogenomic Modeling of Circulating Tumor and Invasive Cells for Prediction of Chemotherapy Response and Resistance in Pancreatic Cancer

PURPOSE: Despite a challenging prognosis, modern cytotoxic therapy can induce tumor responses and extend life in pancreatic adenocarcinoma (PDAC). Pharmacogenomic (PGx) modeling of tumor tissue can predict efficacy of chemotherapeutic agents in preclinical cancer models. We hypothesized that PGx pro...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Yu, Kenneth H., Ricigliano, Mark, Hidalgo, Manuel, Abou-Alfa, Ghassan K., Lowery, Maeve A., Saltz, Leonard B., Crotty, Joseph F., Gary, Kristen, Cooper, Brandon, Lapidus, Rena, Sadowska, Mariola, O'Reilly, Eileen M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346320/
https://ncbi.nlm.nih.gov/pubmed/25107917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0531
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