Pharmacogenomic Modeling of Circulating Tumor and Invasive Cells for Prediction of Chemotherapy Response and Resistance in Pancreatic Cancer

PURPOSE: Despite a challenging prognosis, modern cytotoxic therapy can induce tumor responses and extend life in pancreatic adenocarcinoma (PDAC). Pharmacogenomic (PGx) modeling of tumor tissue can predict efficacy of chemotherapeutic agents in preclinical cancer models. We hypothesized that PGx pro...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Yu, Kenneth H., Ricigliano, Mark, Hidalgo, Manuel, Abou-Alfa, Ghassan K., Lowery, Maeve A., Saltz, Leonard B., Crotty, Joseph F., Gary, Kristen, Cooper, Brandon, Lapidus, Rena, Sadowska, Mariola, O'Reilly, Eileen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346320/
https://ncbi.nlm.nih.gov/pubmed/25107917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0531
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