Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist

Passive Aβ vaccination has shown significant effects on amyloid pathology in pre-depositing APP mice but the results in older mice are inconsistent. A therapeutic effect of LXR and RXR agonists consisting of improved memory deficits and Aβ pathology has been demonstrated in different AD mouse models...

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Bibliographic Details
Published in:J Alzheimers Dis
Main Authors: Fitz, Nicholas F., Castranio, Emilie L., Carter, Alexis Y., Kodali, Ravindra, Lefterov, Iliya, Koldamova, Radosveta
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346309/
https://ncbi.nlm.nih.gov/pubmed/24643138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-132789
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