Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35. Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. Here, we show that p25 is generated following neuronal activity u...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Seo, Jinsoo, Giusti-Rodríguez, Paola, Zhou, Ying, Rudenko, Andrii, Cho, Sukhee, Ota, Kristie T., Park, Christine, Patzke, Holger, Madabhushi, Ram, Pan, Ling, Mungenast, Alison E., Guan, Ji-Song, Delalle, Ivana, Tsai, Li-Huei
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327772/
https://ncbi.nlm.nih.gov/pubmed/24725413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.065
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