Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35. Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. Here, we show that p25 is generated following neuronal activity u...

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Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Seo, Jinsoo, Giusti-Rodríguez, Paola, Zhou, Ying, Rudenko, Andrii, Cho, Sukhee, Ota, Kristie T., Park, Christine, Patzke, Holger, Madabhushi, Ram, Pan, Ling, Mungenast, Alison E., Guan, Ji-Song, Delalle, Ivana, Tsai, Li-Huei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327772/
https://ncbi.nlm.nih.gov/pubmed/24725413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.065
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