Standard Versus Continuous Administration of Capecitabine in Metastatic Breast Cancer (GEICAM/2009-05): A Randomized, Noninferiority Phase II Trial With a Pharmacogenetic Analysis

BACKGROUND. The approved capecitabine regimen as monotherapy in metastatic breast cancer (MBC) is 1,250 mg/m(2) twice daily for 2 weeks on and 1 week off (Cint). Dose modifications are often required because of severe hand-foot syndrome (HFS). We tested a continuous regimen with a lower daily dose b...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncologist
Main Authors: Martín, Miguel, Martínez, Noelia, Ramos, Manuel, Calvo, Lourdes, Lluch, Ana, Zamora, Pilar, Muñoz, Montserrat, Carrasco, Eva, Caballero, Rosalía, García-Sáenz, José Ángel, Guerra, Eva, Caronia, Daniela, Casado, Antonio, Ruíz-Borrego, Manuel, Hernando, Blanca, Chacón, José Ignacio, De la Torre-Montero, Julio César, Jimeno, María Ángeles, Heras, Lucía, Alonso, Rosario, De la Haba, Juan, Pita, Guillermo, Constenla, Manuel, González-Neira, Anna
Format: Artigo
Jezik:Inglês
Izdano: AlphaMed Press 2015
Teme:
Clinical Trial Results
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319639/
https://ncbi.nlm.nih.gov/pubmed/25601966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0379
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