Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2

BACKGROUND: Circadian gene disruptions are associated with the development of psychiatric disorders, including addiction. However, the mechanisms by which circadian genes regulate drug reward remain poorly understood. METHODS: We used mice with a mutation in Npas2, and AAV-shRNA mediated knock-down...

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Pubblicato in:Biol Psychiatry
Autori principali: Ozburn, Angela R., Falcon, Edgardo, Twaddle, Alan, Nugent, Alexandria L., Gillman, Andrea G., Spencer, Sade M., Arey, Rachel N., Mukherjee, Shibani, Lyons-Weiler, James, Self, David W., McClung, Colleen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315729/
https://ncbi.nlm.nih.gov/pubmed/25444159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.07.030
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