REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify stress-inducible mTOR inhibitor REDD1 (regulated in development and DNA damage response 1) as a major molecular target of glucocorticoids, which mediat...

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Dades bibliogràfiques
Publicat a:EMBO Mol Med
Autors principals: Baida, Gleb, Bhalla, Pankaj, Kirsanov, Kirill, Lesovaya, Ekaterina, Yakubovskaya, Marianna, Yuen, Kit, Guo, Shuchi, Lavker, Robert M, Readhead, Ben, Dudley, Joel T, Budunova, Irina
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309667/
https://ncbi.nlm.nih.gov/pubmed/25504525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404601
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