Macrophage-Derived upd3 Cytokine Causes Impaired Glucose Homeostasis and Reduced Lifespan in Drosophila Fed a Lipid-Rich Diet

Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that govern their response to dietary stress. Flies...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Woodcock, Katie J., Kierdorf, Katrin, Pouchelon, Clara A., Vivancos, Valérie, Dionne, Marc S., Geissmann, Frédéric
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304720/
https://ncbi.nlm.nih.gov/pubmed/25601202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.023
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